water channel

Pathways Recommended:	Membrane Transporter/Ion Channel

By Targets:	TRP Channel (1) Apoptosis (1) Fluorescent Dye (1) Liposome (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Metabolic Disease (1)

Targets Recommended: Chloride Channel Calcium Channel HCN Channel CRAC Channel TRP Channel Sodium Channel Potassium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134094

Fluridone	Others	Inflammation/Immunology
Fluridone is a herbicide, particularly to eliminate aquatic plant growth in water reservoirs and irrigation channels. Fluridone is a potent Abscisic acid (ABA) biosynthesis inhibitor, and has anti-inflammatory effects .

HY-B1386

Halazone
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .

HY-N0322A

Cholesterol (Water Soluble) 15+ Cited Publications	Liposome	Others
Cholesterol Water Soluble can be used for the research of the effects of cholesterol on the potassium currents in inner hair cells (IHCs). Cholesterol is an integral component of the cell membrane and regulates the activity of ion channels in the lipid bilayer .

HY-D1368

BDP FL amine hydrochloride	Fluorescent Dye	Others
BDP FL amine hydrochloride is a borondipyrromethene dye with good water solubility. BDP FL amine hydrochloride can be read on the FAM channel .

HY-148752

TRPV1 activator-2

TRP Channel Metabolic Disease

TRPV1 activator-2 (compound 9), a capsaicin head analog, makes specific interactions with channel residues at the lipid-water .

TRPV1 activator-2	TRP Channel	Metabolic Disease
TRPV1 activator-2 (compound 9), a capsaicin head analog, makes specific interactions with channel residues at the lipid-water .

HY-N6016

Bacopaside II 1 Publications Verification	Apoptosis	Cancer
Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis .

Cat. No.	Product Name

HY-L145

Antihypertensive Compound Library	481 compounds
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 481 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Antihypertensive Compound Library

481 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 481 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Cat. No.	Product Name	Type

HY-D1368

BDP FL amine hydrochloride	Fluorescent Dyes/Probes
BDP FL amine hydrochloride is a borondipyrromethene dye with good water solubility. BDP FL amine hydrochloride can be read on the FAM channel .

Cat. No.	Product Name	Type

HY-N0322A

Cholesterol (Water Soluble) 15+ Cited Publications	Drug Delivery
Cholesterol Water Soluble can be used for the research of the effects of cholesterol on the potassium currents in inner hair cells (IHCs). Cholesterol is an integral component of the cell membrane and regulates the activity of ion channels in the lipid bilayer .

Cat. No.	Product Name	Target	Research Area

HY-P2967

α-Hemolysin (Staphylococcus aureus)	Peptides	Others
α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K ⁺ and Ca ²⁺ ion transport, leading to necrotic death of target cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0322A

Cholesterol (Water Soluble) 15+ Cited Publications	Structural Classification Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Steroids	Liposome
Cholesterol Water Soluble can be used for the research of the effects of cholesterol on the potassium currents in inner hair cells (IHCs). Cholesterol is an integral component of the cell membrane and regulates the activity of ion channels in the lipid bilayer .

HY-N6016

Bacopaside II 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Cancer	Apoptosis
Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis .

Species:	Human (3) Mouse (3) Rat (1)
Tag:	His (6) SUMO (3) Tag Free (1)
Source:	E. coli Cell-free (5) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702213

	AQP2 Protein, Mouse (Cell-Free, His) Aquaporin-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; water channel protein for renal collecting duct	Mouse	E. coli Cell-free
	AQP2 is a homotetrameric protein that plays a key role in renal water homeostasis. It acts as a water-specific channel, facilitating the movement of water across the plasma membrane of the renal collecting duct. AQP2 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived AQP2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of AQP2 Protein, Mouse (Cell-Free, His) is 271 a.a., with molecular weight of 30.5 kDa.

HY-P702214

	AQP2 Protein, Rat (Cell-Free, His) Aquaporin-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; water channel protein for renal collecting duct	Rat	E. coli Cell-free
	AQP2 Protein, a water-specific channel, imparts high water permeability to renal collecting duct plasma membranes, facilitating water movement along osmotic gradients. Crucial for renal water homeostasis, AQP2 significantly regulates water reabsorption in the kidneys. Existing as a homotetramer, it is a key component in selectively transporting water through renal tissues. AQP2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived AQP2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of AQP2 Protein, Rat (Cell-Free, His) is 271 a.a., with molecular weight of 30.4 kDa.

HY-P72085

	AQP1 Protein, Human (His-SUMO) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; channel forming integral protein 28kDa; channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; water channel protein CHIP 29; water channel protein CHIP29; water channel protein for red blood cells and kidney proximal tubule	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of AQP1 Protein, Human (His-SUMO) is 50 a.a., with molecular weight of ~21.6 kDa.

HY-P700377

	Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; channel forming integral protein 28kDa; channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; water channel protein CHIP 29; water channel protein CHIP29; water channel protein for red blood cells and kidney proximal tubule	Human	E. coli Cell-free
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) is the recombinant human-derived Aquaporin-1/AQP1 protein, expressed by E. coli Cell-free , with N-SUMO, N-6*His labeled tag. The total length of Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) is 268 a.a., with molecular weight of 41.3 kDa.

HY-P702215

	AQP4 Protein, Mouse (Cell-Free) Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4	Mouse	E. coli Cell-free
	The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with tag free. The total length of AQP4 Protein, Mouse (Cell-Free) is 323 a.a., with molecular weight of 34.8 kDa.

HY-P702216

	AQP4 Protein, Mouse (Cell-Free, His) Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4	Mouse	E. coli Cell-free
	The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of AQP4 Protein, Mouse (Cell-Free, His) is 323 a.a., with molecular weight of 40.5 kDa.

HY-P72087

	AQP4 Protein, Human (His-SUMO) AQP 4; AQP-4; AQP4; AQP4_HUMAN; Aquaporin type 4; Aquaporin-4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; Mercurial-insensitive water channel; MGC22454; MIWC; WCH 4; WCH4	Human	E. coli
	The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His-SUMO) is the recombinant human-derived AQP4 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of AQP4 Protein, Human (His-SUMO) is 71 a.a., with molecular weight of ~27 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81404

Aquaporin 1 Antibody (YA1149)

AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; water channel protein for red blood cells and kidney proximal tubule
IHC-P Human

HY-P83459A

Aquaporin 4 Antibody aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.	WB, IHC-P, IHC-F, Flow-Cyt, IF	Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep

HY-P83459

Aquaporin 4 Antibody (YA3204)

AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4
IHC-P Human, Rat

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water channel

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

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Recombinant Proteins

Antibodies

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